Which of the following statements about the two most common syndromes identified by MyRisk is true?

• A. They are not related to hereditary cancer risk
• B. They are identified only in male patients
• C. They are only relevant to colorectal cancer
• D. HBOC and Lynch syndrome are the two most common syndromes identified by MyRisk

Answer: (D)

The main idea is that hereditary cancer risk tools like MyRisk most commonly identify two well-known syndromes: HBOC and Lynch syndrome. This is true because HBOC, caused by BRCA1/BRCA2 variants, and Lynch syndrome, caused by germline defects in mismatch repair genes, are the most frequently detected inherited cancer predisposition syndromes in broad screening panels. They underline a broad spectrum of cancer risks beyond a single site, including breast and ovarian cancers for HBOC and colorectal (plus endometrial) cancers for Lynch. These syndromes cross sex and affect more than just colorectal cancer, which is why the statement that HBOC and Lynch syndrome are the two most common identified by MyRisk is the best choice.