Which interval is a typical MRD monitoring frequency?

• A. Every 1-2 weeks
• B. Every 3-6 months
• C. Every 2-3 years
• D. Biweekly

Answer: (B)

MRD surveillance is most practical when done at regular, moderate intervals that balance catching relapse early with the realities of testing and patient burden. After achieving remission, checking MRD every 3–6 months during the early years of follow-up is a common approach because relapse most often occurs within the first few years, and semiannual checks provide timely information to guide treatment decisions without over-testing. Very frequent monitoring (weekly or biweekly) is typically reserved for active treatment or immediate post-treatment assessment, while waiting years between checks risks catching relapse too late. So, every 3–6 months is the best-balanced interval for routine MRD monitoring.