What types of samples can be used for MyRisk testing?

• A. Blood
• B. Saliva
• C. Blood or saliva
• D. Urine

Answer: (C)

The main concept here is that MyRisk testing accepts more than one specimen type because it analyzes germline DNA and has been validated to work with DNA from both sources. Blood provides high-quality, high-quantity genomic DNA that’s routinely used for sequencing panels. Saliva offers a convenient, non-invasive collection method and, with proper stabilization, yields DNA suitable for the same kind of sequencing and analysis. Both options are considered valid because the lab has demonstrated that DNA from either source meets the necessary quality and quantity for the multi-gene hereditary cancer panel.

Urine isn’t used for this test because it doesn’t reliably provide the germline DNA required for comprehensive panel analysis; it usually isn’t validated for this purpose, and the DNA obtained is not consistently adequate for accurate sequencing.