What is the inheritance pattern of HBOC and Lynch syndrome, and what does this imply for first-degree relatives?

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Multiple Choice

What is the inheritance pattern of HBOC and Lynch syndrome, and what does this imply for first-degree relatives?

Explanation:
HBOC and Lynch syndrome are inherited in an autosomal dominant fashion. This means a single mutated copy of the relevant gene is enough to increase cancer risk. Because of this pattern, each first-degree relative (parent, child, or full sibling) of an affected person has a 50% chance of carrying the pathogenic variant. This makes family-based testing important: if a relative carries the mutation, they can pursue targeted surveillance and risk-reducing options; if they do not carry it, their inherited risk from these mutations is not elevated.

HBOC and Lynch syndrome are inherited in an autosomal dominant fashion. This means a single mutated copy of the relevant gene is enough to increase cancer risk. Because of this pattern, each first-degree relative (parent, child, or full sibling) of an affected person has a 50% chance of carrying the pathogenic variant. This makes family-based testing important: if a relative carries the mutation, they can pursue targeted surveillance and risk-reducing options; if they do not carry it, their inherited risk from these mutations is not elevated.

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