What does HER2-positive mean?

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Multiple Choice

What does HER2-positive mean?

Explanation:
Her2-positive means there is an excess of the HER2 growth receptor on the surface of tumor cells. This overexpression, usually due to gene amplification, drives cancer cell growth and also provides a target for HER2-directed therapies like trastuzumab. It’s not about a mutation in the HER2 gene, nor about the receptor being inactivated or absent. Diagnostic tests detect overexpression or amplification—immunohistochemistry shows strong HER2 protein expression, and FISH testing confirms gene amplification.

Her2-positive means there is an excess of the HER2 growth receptor on the surface of tumor cells. This overexpression, usually due to gene amplification, drives cancer cell growth and also provides a target for HER2-directed therapies like trastuzumab. It’s not about a mutation in the HER2 gene, nor about the receptor being inactivated or absent. Diagnostic tests detect overexpression or amplification—immunohistochemistry shows strong HER2 protein expression, and FISH testing confirms gene amplification.

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