What are the two most common syndromes identified by MyRisk?

• A. HBOC and Lynch syndrome
• B. BRCA1/2 Syndrome and Li-Fraumeni
• C. Peutz-Jeghers and Cowden
• D. Lynch and Li-Fraumeni

Answer: (A)

On a multi-gene panel like MyRisk, the two most commonly identified hereditary cancer syndromes are Hereditary Breast and Ovarian Cancer (HBOC) and Lynch syndrome. BRCA1/BRCA2 mutations drive HBOC and are the leading genetic cause of hereditary breast and ovarian cancer, so they show up very often on these panels. Lynch syndrome, caused by pathogenic variants in mismatch repair genes (such as MLH1, MSH2, MSH6, PMS2, and related EPCAM alterations), is the most common hereditary colorectal cancer syndrome and is also routinely included and detected on these tests. While other syndromes like Li-Fraumeni, Peutz-Jeghers, and Cowden are important, they occur less frequently in broad testing populations, so they appear less often on MyRisk results.